Offer comparison

Pharma cash or biotech equity?

Put two offers side by side and see what the equity is really worth once you account for clinical-stage risk.

Offer comparison: pharma cash vs. biotech equity

Equity on paper isn't equity in your pocket. Each company stage starts with default odds and outcomes that you can edit. For public companies, the defaults assume today's share price is fair (expected value ≈ 1× paper) but spread the outcomes much wider for clinical-stage companies. Private equity gets a discount because you can't sell it. The tool compares expected value with the bad and good cases, before tax.

Offer A
Equity risk assumptions
Offer B
Equity risk assumptions
Big Pharma CoClinical-stage biotechDifference (B − A)
Base salary$260,000$245,000-$15,000
Target bonus$65,000$73,500+$8,500
401(k) match$15,600$9,800-$5,800
ESPP gain (est.)$3,740$6,375+$2,635
Equity per year (paper)$60,000$100,000+$40,000
Equity per year (expected)$61,500$100,500+$39,000
Sign-on (year 1)$40,000$25,000-$15,000
Year-1 total (expected)$445,840$460,175+$14,335
4-yr total on paper$1,657,360$1,763,700+$106,340
4-yr total (expected)$1,663,360$1,765,700+$102,340
4-yr total, bad case$1,609,360$1,443,700-$165,660
4-yr total, good case$1,717,360$2,363,700+$646,340
Clinical-stage biotech comes out $102,340 ahead over 4 years on expected value. In the bad case, Big Pharma Co pays $1,609,360 and Clinical-stage biotech pays $1,443,700, a gap of $165,660. To match Big Pharma Co, Clinical-stage biotech's equity needs to end up worth at least 0.75× its paper value.

ESPP value assumes you contribute up to the IRS limit (or 15% of base); the lookback case assumes an average gain of about 30% on contributions. Pre-tax, US only. Also consider layoff risk, title, scope and runway, which a calculator can't price.

Coming next

Built for the moments that only happen in biotech.

Taxes

RSU withholding gap

Your company withholds 22% on vests, but your bracket may be 35%. See what you'll owe in April before it's a surprise.

Compliance

10b5-1 & trading windows

Plan sales around blackout periods and set up a 10b5-1 plan before the next readout.

Playbook

"We're being acquired"

What happens to your unvested RSUs, underwater options and ESPP in a deal.

Get the full tracker first

Live share prices, vest reminders, readout-risk alerts and a biotech equity newsletter. Free for early members.

We'll only use your email for BiotechFIRE updates. See our privacy policy.